James E Ferrell, Director
Cell cycle regulation, especially M-phase regulation, in Xenopus embryos and mammalian cell lines; systems biology of signal transduction pathways.
Tobias Meyer, Co-Director
Ca2+, lipid second messenger and small GTPase signaling pathways; Control of cell polarity, chemotaxis, and collective migration as well as cell proliferation and differentiation decisions.
Jefferey D Axelrod
How signal transduction pathways regulate morphogenesis - the emergence of spatial organization - during development. Uncovering the mechanisms controlling planar cell polarity using Drosophila and mouse as model organisms.
James K Chen
Developmental signaling pathways and their roles in embryonic patterning and oncogenesis; zebrafish models of tissue patterning and regeneration; synthetic chemistry and chemical biology.
Building computational models of complex biological processes to guide an experimental program and accelerate discovery.
Physical mechanisms of cell shape determination, detection, and maintenance in bacteria; membrane organization; cell division.
Michael Z Lin
Protein engineering applied to sensing or controlling cell biology, including fluorescent proteins, optogenetic actuators, synthetic signaling nodes, and drug-controlled production switches.
W. James Nelson
A major focus of the Nelson laboratory is to understand the regulation of cell-cell adhesion. We provided the first live cell analysis of the distributions of E-cadherin, actin and Rho family GTPase activities during initial cell-cell adhesion, reconstituted protein-protein interactions in the cadherin-catenin-actin complex with surprising results, and extended these studies to Dictyostelium, C. elegans and zebrafish. Recently, we worked out how the cadherin-catenin complex interacts with actin filaments through a force-dependent α-catenin catch bond, and found evidence for tension-dependent regulation of cell cycle progression by the E-cadherin/catenin complex.
Jan M Skotheim
Cell cycle control, maternal to zygotic transition, cell size control, MAPK signaling, systems and quantitative biology.
Uncovering the molecular mechanisms controlling cell differentiation and its critical role in diabetes, obesity, and cancer; understanding how cell signaling and chromatin interact to decide cell fate.
Interactions between infectious bacteria and the human host cell actin cytoskeleton. Understanding the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis.
Claire Tomlin (UC Berkeley)
Modeling and Analysis of Biological Cell Networks. Modeling the protein network controlling planar cell polarity within a Drosophila wing.
Thomas J Wandless
Cellular mechanisms responsible for protein quality control surveillance and degradation; invention of new technologies to enable biomedical research; synthetic chemistry and chemical biology.
Last modified Tuesday, 16-June-2015